Dual-active-ingredient, insecticidal nets for preventing malaria: a systematic review protocol

Background: Malaria is caused by the Plasmodium parasite and a highly transmissible disease representing significant global public health burden. The provision of insecticide-treated mosquito nets (ITNs) has contributed to reduction malaria across endemic countries. However, detection insecticide resistance in many vector species potentially threatens long-term effectiveness ITNs. A novel method reduce impact treat with multiple active ingredients. Methods analysis: This review will comprehensively search literature (both published unpublished) for any studies investigating treated ingredients, known henceforth as dual-active-ingredient (DAI) DAI ITNs interest include those pyrethroid non-pyrethroid (review question 1) or an insect growth regulator 2). Studies be screened meet inclusion criteria minimum two authors, followed assessment risk bias (using appropriate tools randomised non-randomised studies) extraction relevant information using structured forms independent authors. Meta-analyses carried out where possible epidemiological outcomes subgrouping considered. Certainty evidence established GRADE assessments. Ethics dissemination: full report submitted Vector Control Insecticide Resistance Unit, Global Program, WHO. version this publication open access peer-reviewed journal. inform development WHO recommendations regarding use prevention malaria. systematic does not require ethics approval it primary studies. Registration: PROSPERO ID: CRD42022333044